Also called Hemoglobin S, Hgb Solubility, Siclke Cell Solubility Test, Sickledex. This test is done to tell if you have abnormal hemoglobin that causes sickle cell disease and sickle cell trait. In sickle cell disease, a person has two abnormal hemoglobin S genes. A person with sickle cell trait has only one of the problem hemoglobin S genes and no symptoms, or only mild ones. However, this test does not tell the difference between these two conditions. Another test called hemoglobin electrophoresis is needed to do so. Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.